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Related Experiment Videos

Does cyclo(His-Pro) act like amphetamine?

H Mizuma1, I Shimizu, C Hilton

  • 1Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.

Life Sciences
|January 1, 1994
PubMed
Summary
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Cyclo(His-Pro) (CHP) does not mimic amphetamine (AMP) effects. Unlike AMP, CHP did not decrease food intake or increase locomotor activity, indicating it is not an amphetamine-like peptide.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Biochemistry

Background:

  • Cyclo(His-Pro) (CHP) exhibits dopaminergic agonist properties in some pharmacologic tests.
  • CHP has been observed to augment the effects of amphetamine (AMP).

Purpose of the Study:

  • To investigate whether cyclo(His-Pro) (CHP) functions as an amphetamine-like peptide.
  • To compare the neurochemical and behavioral effects of CHP and AMP.

Main Methods:

  • Comparison of CHP and AMP in four established amphetamine-responsive tests: food intake, locomotor activity, dopamine uptake, and modulation of amphetamine and mazindol binding sites.
  • Assessment of acute peripheral administration effects and chronic administration effects on binding sites.

Main Results:

Related Experiment Videos

  • Peripheral amphetamine administration decreased food intake and increased locomotor activity and stereotypy, while CHP had no significant effect on these measures.
  • Chronic CHP administration altered striatal binding sites, decreasing amphetamine binding and increasing mazindol binding.
  • Chronic amphetamine administration decreased both amphetamine and mazindol binding sites.

Conclusions:

  • The distinct effects of CHP and AMP on behavior and neurochemical markers demonstrate a clear dissociation between the two compounds.
  • Cyclo(His-Pro) (CHP) is not an amphetamine-like peptide.