Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mucosal origin of AIDS

A S Bourinbaiar1

  • 1Department of Pediatrics, NYU Medical Center, NY 10016.

Medical Hypotheses
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

The natural history of Acquired Immunodeficiency Syndrome (AIDS) involves HIV transmission via mucosal linings. Failures in mucosal immunity contribute to AIDS symptoms like enteropathy and respiratory infections, leading to death.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapeutic AIDS vaccines.

Current pharmaceutical design·2006
Same author

Effect of an oral therapeutic HIV-1 vaccine on AIDS patients with CD4 count above 250 cells/mm3.

Acta virologica·2004
Same author

Increased body weight and improved quality of life in AIDS patients following V-1 Immunitor administration.

European journal of clinical nutrition·2003
Same author

Nonoxynol-9 as a xenobiotic with endocrine activity.

AIDS (London, England)·1997
Same author

Effect of the oral anti-ulcer agent, cimetidine, on HIV type 1 replication.

AIDS research and human retroviruses·1997
Same author

The role of carboxy-terminal portion of beta subunit of human chorionic gonadotropin in human immunodeficiency virus infection.

Life sciences·1997

Area of Science:

  • Immunology
  • Virology
  • Gastroenterology

Background:

  • Acquired Immunodeficiency Syndrome (AIDS) is primarily transmitted through sexual contact and breast milk, crossing mucosal barriers.
  • The digestive and reproductive tracts are key sites for Human Immunodeficiency Virus (HIV) entry.
  • Intraepithelial mucosal lymphocytes are crucial for immune defense at barrier surfaces.

Purpose of the Study:

  • To investigate the role of mucosal immunity in the natural history of AIDS.
  • To understand the link between mucosal immunity failure and AIDS-related pathologies.

Main Methods:

  • Analysis of the natural history of AIDS.
  • Review of immunological responses at mucosal sites.

Main Results:

Related Experiment Videos

  • Mucosal surfaces are critical for HIV transmission.
  • Intraepithelial mucosal lymphocytes constitute a significant portion of the body's immune cells.
  • Impaired mucosal immunity is associated with enteropathy and respiratory infections in AIDS patients.

Conclusions:

  • Failure of mucosal immunity is a primary driver of AIDS pathogenesis.
  • Targeting mucosal immunity may offer therapeutic strategies for HIV/AIDS.