Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Interstitial lung disease in children

R E Bokulic¹, B C Hilman

¹Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio.

Pediatric Clinics of North America

|June 1, 1994

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ten month old infant with wheezing for six months.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2000

Same author

Pediatric tuberculosis: problems in diagnosis and issues in management.

The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society·1999

Same author

Chronic interstitial lung disease.

Clinical pediatrics·1998

Same author

Immunodeficiency with elevated IgM, lymphoid hyperplasia, autoimmune anemia, and thrombocytopenia.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·1998

Same author

Genetic and immunologic aspects of cystic fibrosis.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·1997

Same author

Radiological case of the month. Posttraumatic pseudocysts.

Archives of pediatrics & adolescent medicine·1997

Same journal

Barriers, Breakthroughs, and the Future of Pediatric Dermatologic Care.

Pediatric clinics of North America·2026

Same journal

Advancing Pediatric Dermatology: Innovations in Care and Access.

Pediatric clinics of North America·2026

Same journal

No Child Left Behind: Advancing Access in Pediatric Dermatology, a 4-Year, Single-Center Experience.

Pediatric clinics of North America·2026

Same journal

Telemedicine and Access to Pediatric Dermatology Care.

Pediatric clinics of North America·2026

Same journal

Inequitable Reimbursement for Pediatric Providers: A Review of Structural Factors that Disincentivize the Care of Children.

Pediatric clinics of North America·2026

Same journal

Medical Photography's Power to Change Medical Care.

Pediatric clinics of North America·2026

See all related articles

Interstitial lung disease (ILD) in children involves lung inflammation and potential fibrosis. Early diagnosis and anti-inflammatory therapy are crucial for better outcomes, but standardized guidelines are lacking.

Area of Science:

Pediatric Pulmonology
Pathogenesis of Lung Diseases
Fibrotic Interstitial Lung Disease

Background:

Interstitial lung disease (ILD) in children is a complex group of disorders characterized by inflammation of the lung interstitium.
This inflammation can lead to alveolar wall thickening, fibrosis, and impaired lung function.
Understanding the pathogenic mechanisms, often extrapolated from adult and animal models, is key to managing pediatric ILD.

Purpose of the Study:

To apply known pathogenic mechanisms of ILD from adult and animal models to understand its development in children.
To highlight the challenges in diagnosing and managing pediatric ILD due to subtle, nonspecific clinical manifestations and lack of consensus criteria.
To emphasize the need for early diagnosis and anti-inflammatory therapy to prevent disease progression.

Related Experiment Videos

Main Methods:

Extrapolation of pathogenic mechanisms from adult and animal models of ILD.
Review of clinical manifestations, diagnostic challenges, and therapeutic approaches in pediatric ILD.
Discussion of the limitations in current understanding and management due to lack of uniform guidelines and multicenter data.

Main Results:

Pediatric ILD shares histologic characteristics with adult ILD, primarily inflammation and potential fibrosis.
Clinical diagnosis is challenging due to nonspecific symptoms; histologic examination is crucial.
Therapy focuses on reducing inflammation to prevent fibrosis, but lacks standardized protocols.

Conclusions:

A deeper understanding of ILD pathogenesis in children requires applying knowledge from other models.
Standardized diagnostic criteria, therapeutic guidelines, and prognostic indicators are urgently needed for effective pediatric ILD management.
A multicenter approach is essential to gather sufficient data for objective evaluation and to establish optimal management strategies.