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[Toxic lung damage caused by mitomycin C]
G Lenci1, J Müller-Quernheim, J Lorenz
1Abteilung für Pneumologie, Johannes Gutenberg-Universität, Mainz.
Pneumologie (Stuttgart, Germany)
|March 1, 1994
Abstract:
Lung toxicity is one of the rare side effects of mitomycin C (MMC), an effective antineoplastic agent. There have been only few reports on pulmonary damage after MMC monotherapy. We describe a case of a pulmonary reaction following MMC monotherapy. The patient was examined including bronchoalveolar lavage (BAL) and transbronchial lung biopsy. BAL yielded the diagnosis of a lymphocyte alveolitis with normal CD4/CD8 ratio within the T lymphocytes. Histologically a florid alveolitis was diagnosed. Radiological and CT findings including HR-CT are described.