Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Eicosanoids in septic shock in rats]

I Cernak1, J Savić, G Andelić

  • 1Vojnomedicinska akademija, Institut za medicinska istrazivanja.

Vojnosanitetski Pregled
|November 1, 1993
PubMed
Summary

Peptidoleukotrienes play a key role in septic shock pathogenesis. This study measured eicosanoid levels in rats, finding these lipoxygenase products are crucial in the septic shock inflammatory response.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative proteomic profiling in brain subregions of mice exposed to open-field low-intensity blast reveals position-dependent blast effects.

Shock waves·2026
Same author

Utility of MRI in detection of PET-CT proven local recurrence of pancreatic adenocarcinoma after surgery.

Medical oncology (Northwood, London, England)·2024
Same author

Influenza outbreaks in Ontario hospitals, 2012-2016.

Canada communicable disease report = Releve des maladies transmissibles au Canada·2019
Same author

Environmental toxicology of blast exposures: injury metrics, modelling, methods and standards.

Journal of the Royal Army Medical Corps·2018
Same author

Guidelines for reproducing blast exposures in the laboratory.

Journal of the Royal Army Medical Corps·2018
Same author

Guidelines for conducting epidemiological studies of blast injury.

Journal of the Royal Army Medical Corps·2018

Area of Science:

  • Biochemistry
  • Pathophysiology
  • Pharmacology

Context:

  • Sepsis-induced organ dysfunction is a major clinical challenge.
  • Eicosanoids, including thromboxane A2 (TxA2), prostaglandin E2 (PGE2), and peptidoleukotrienes, are implicated in inflammatory processes.
  • Understanding their specific roles in septic shock is crucial for developing targeted therapies.

Purpose:

  • To investigate the dynamic changes in TxA2, PGE2, and peptidoleukotriene levels in the liver during surgically induced septic shock in rats.
  • To assess the impact of phospholipase A2 and cyclooxygenase inhibition on these eicosanoid pathways and related physiological parameters.
  • To elucidate the specific contribution of different eicosanoid classes to the pathogenesis of septic shock.

Summary:

  • Surgically induced septic shock in rats led to measurable changes in hepatic eicosanoid levels.
  • Administration of methylprednisolone (phospholipase A2 inhibitor) or indomethacin (cyclooxygenase inhibitor) modulated these changes.
  • Peptidoleukotrienes, derived from arachidonic acid via the lipoxygenase pathway, were identified as the primary eicosanoids involved in septic shock pathogenesis.

Impact:

  • This research highlights peptidoleukotrienes as key mediators in septic shock.
  • Findings suggest that targeting the lipoxygenase pathway may offer a therapeutic strategy for managing septic shock.
  • The study provides a foundation for further investigation into specific eicosanoid-targeted interventions for sepsis.

Related Experiment Videos