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Decrease in ornithine decarboxylase activity after eradication of Helicobacter pylori

K Alam1, F L Arlow, C K Ma

  • 1Division of Gastroenterology, Henry Ford Hospital, Detroit, Michigan.

The American Journal of Gastroenterology
|June 1, 1994
PubMed
Summary
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Successful Helicobacter pylori (HP) eradication significantly reduces ornithine decarboxylase (ODC) activity in gastric mucosa. This decrease in ODC activity suggests reduced cellular proliferation, potentially lowering the risk of gastric cancer development.

Area of Science:

  • Gastroenterology
  • Oncology
  • Molecular Biology

Background:

  • Helicobacter pylori (HP) infection is linked to gastric cancer development.
  • Gastric cancer arises from a sequence of mucosal changes, including dysplasia, associated with increased cellular proliferation.
  • Ornithine decarboxylase (ODC) activity is a marker of cellular proliferation and is elevated in gastrointestinal neoplasia.

Purpose of the Study:

  • To investigate if ornithine decarboxylase (ODC) activity in gastric mucosa changes after successful Helicobacter pylori (HP) eradication.
  • To assess the impact of HP eradication on mucosal proliferative activity.

Main Methods:

  • Gastric antral and body biopsies were collected from 17 HP-positive patients.
  • Biopsies were analyzed for ODC activity and histology before and 4-6 weeks after successful triple therapy for HP.

Related Experiment Videos

  • Warthin Starry stain was used for histological assessment.

    • Main Results:

    • Mean ODC activity significantly decreased in both antral and body mucosa post-HP eradication compared to pre-treatment levels.
    • Antral mucosa ODC activity decreased from 147 +/- 26 to 80 +/- 15 pmol CO2/mg protein/h (p < 0.05).
    • Body mucosa ODC activity decreased from 76 +/- 21 to 20 +/- 5 pmol CO2/mg protein/h (p < 0.05).

    Conclusions:

    • Successful eradication of HP leads to a significant reduction in gastric mucosal ODC activity.
    • This reduction in ODC activity indicates decreased mucosal proliferative activity.
    • HP eradication may potentially reduce the future risk of gastric cancer by lowering cellular proliferation.