Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Alcohol and platelet function

R Rubin¹, M L Rand

¹Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Alcoholism, Clinical and Experimental Research

|February 1, 1994

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Jamaican Haemophilia Registry: Describing the burden of disease.

Haemophilia : the official journal of the World Federation of Hemophilia·2018

Same author

Development of a Thai version of the paediatric bleeding assessment tool (Thai paediatric-BAT) suitable for use in children with inherited mucocutaneous bleeding disorders.

Haemophilia : the official journal of the World Federation of Hemophilia·2017

Same author

Acquired von Willebrand syndrome in paediatric patients with congenital heart disease: challenges in the diagnosis and management of this rare condition.

Haemophilia : the official journal of the World Federation of Hemophilia·2014

Same author

Normal range of bleeding scores for the ISTH-BAT: adult and pediatric data from the merging project.

Haemophilia : the official journal of the World Federation of Hemophilia·2014

Same author

Randomised clinical trial: pre-dosing with taribavirin before starting pegylated interferon vs. standard combination regimen in treatment-naïve patients with chronic hepatitis C genotype 1.

Alimentary pharmacology & therapeutics·2012

Same author

Diannexin, an annexin A5 homodimer, binds phosphatidylserine with high affinity and is a potent inhibitor of platelet-mediated events during thrombus formation.

Journal of thrombosis and haemostasis : JTH·2012

Same journal

COVID-19 pandemic-related changes in utilization of telehealth and treatment overall for alcohol use problems.

Alcoholism, clinical and experimental research·2022

Same journal

The relationship between fathers' heavy episodic drinking and fathering involvement in five Asia-Pacific countries: An individual participant data meta-analysis.

Alcoholism, clinical and experimental research·2022

Same journal

Screening for hazardous alcohol use in the Emergency Department: Comparison of phosphatidylethanol with the Alcohol Use Disorders Identification Test and the Timeline Follow-back.

Alcoholism, clinical and experimental research·2022

Same journal

Combination treatment with varenicline and naltrexone reduces World Health Organization risk drinking levels.

Alcoholism, clinical and experimental research·2022

Same journal

College students' virtual and in-person drinking contexts during the COVID-19 pandemic.

Alcoholism, clinical and experimental research·2022

Same journal

Does state repeal of alcohol exclusion laws increase problem drinking?

Alcoholism, clinical and experimental research·2022

See all related articles

Moderate alcohol consumption may protect against coronary artery disease by inhibiting platelet activity. Ethanol

Area of Science:

Cardiovascular Science
Pharmacology
Hematology

Background:

Epidemiological studies suggest moderate alcohol intake is linked to reduced coronary artery disease complications.
Ethanol's potential cardioprotective effect may stem from its influence on platelet function.

Purpose of the Study:

To review experimental evidence on how ethanol affects platelet responses.
To discuss the acute effects of ethanol on platelet function in vivo and ex vivo.
To explore ethanol's inhibitory impact on phospholipase A2 in stimulated platelets.

Main Methods:

Review of experimental observations regarding ethanol's effect on platelets.
Analysis of in vivo and ex vivo studies on acute ethanol exposure.
Examination of ethanol's in vitro effects on stimulated platelet pathways.

Related Experiment Videos

Main Results:

Ethanol has been observed to inhibit platelet responses to physiological agonists.
Acute ethanol exposure, both in vivo and ex vivo, affects platelet function.
In vitro studies show ethanol inhibits phospholipase A2 in stimulated platelets.

Conclusions:

Ethanol exerts inhibitory effects on platelet activity, potentially contributing to cardiovascular protection.
Platelet defects in alcoholics may be multifactorial, influenced by metabolic factors.
Further research is needed to fully elucidate ethanol's interaction with platelet signal transduction pathways.