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Positivity of patch tests in cutaneous reaction to diclofenac. Two case reports
A Romano1, F Pietrantonio, M Di Fonso
1Istituto di Clinica Medica, Università Cattolica del S. Cuore, Rome, Italy.
Allergy
|January 1, 1994
Abstract:
Immune-mediated reactions to NSAIDs are unusual. We have observed two cases of maculopapular eruptions occurring 48-72 h after administration of diclofenac sodium. Patch tests performed with diclofenac were positive. The histopathologic findings resembled those of contact dermatitis with different degrees of dermal involvement. Clinical, allergologic, and histopathologic patterns strongly suggest a type IV mechanism of hypersensitivity. Patch tests play an important role in the assessment of possible immunologic mechanisms underlying cutaneous reactions to drugs.