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Effect of intravenous lidocaine on intraabdominal pressure response to airway stimulation
M Nakayama1, S Fujita, N Kanaya
1Department of Anesthesiology, Sapporo Medical University and Hospital, Japan.
Abstract:
We evaluated the effect of intravenous (i.v.) lidocaine (1 or 2 mg/kg) on increases in intraabdominal pressure (IAP) due to carinal stimulation in anesthetized patients. IAP was measured continuously using a transurethral bladder catheter. Before administration of lidocaine, carinal stimulation by suction catheter increased IAP compared with baseline values (P < 0.05). After i.v. administration of 1 mg/kg of lidocaine, carinal stimulation produced no change in IAP for 5 min, but IAP increased more than baseline at 7 min (P < 0.05); 2 mg/kg of lidocaine suppressed increase in IAP due to carinal stimulation until 7 min. Changes in IAP at 7 min were 42.2 +/- 12.2 mmHg in the 1 mg/kg group and 10.8 +/- 2.6 mmHg in the 2 mg/kg (P < 0.05). We conclude that increase in IAP caused by carinal stimulation is attenuated by i.v. lidocaine, and this effect continues for 5 min from 1 mg/kg of lidocaine and at least for 7 min from 2 mg/kg after administration.