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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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Inflammatory Bowel Disease II: Ulcerative Colitis01:20

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Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
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Inflammatory Bowel Disease III: Crohn's Disease01:25

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

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Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
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Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
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Collagenous colitis and lymphocytic colitis

J M Zeroogian1, S Chopra

  • 1Department of Medicine, Beth Israel Hospital, Boston, Massachusetts.

Annual Review of Medicine
|January 1, 1994
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Summary
This summary is machine-generated.

Collagenous colitis and lymphocytic colitis cause chronic watery diarrhea in middle-aged adults. While endoscopy appears normal, biopsies reveal inflammation and collagen changes, often responding to sulfasalazine or prednisone.

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Area of Science:

  • Gastroenterology
  • Histopathology

Background:

  • Collagenous colitis and lymphocytic colitis are emerging causes of chronic watery diarrhea.
  • These conditions predominantly affect middle-aged individuals.
  • Standard endoscopic examination often yields normal results.

Purpose of the Study:

  • To summarize the key features of collagenous and lymphocytic colitis.
  • To highlight the diagnostic challenges and histological findings.
  • To discuss potential etiologies and treatment options.

Main Methods:

  • Review of existing literature on collagenous and lymphocytic colitis.
  • Analysis of histological findings in colonic biopsies.
  • Evaluation of clinical presentation, pathogenesis, and treatment efficacy.

Main Results:

  • Histological examination reveals inflammatory changes in the colonic mucosa.
  • Collagenous colitis is characterized by subepithelial collagen deposition.
  • Both conditions can present with spontaneous remissions and relapses.

Conclusions:

  • Collagenous and lymphocytic colitis are distinct clinicopathological entities.
  • Diagnosis relies on histological assessment of colonic biopsies.
  • Sulfasalazine and prednisone are effective treatments for symptomatic patients.