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Oxidation of low molecular weight chloroalkanes by cytochrome P450CAM
1Department of Biochemistry, Gortner Laboratory, University of Minnesota, St. Paul 55108.
Biochemical and Biophysical Research Communications
|May 30, 1994
Abstract:
Cytochrome P450CAM from Pseudomonas putida G786 oxidized chlorinated ethanes and 1,2-dichloropropane. The rate of NADH oxidation decreased with decreasing chlorine substitution. The single detectable oxidation products of 1,1,1-trichloroethane and 1,2-dichloropropane were 1,1,1-trichloroethanol and chloroacetone, respectively. Organic product formation was largely uncoupled from NADH oxidation.