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Related Experiment Videos

Episodic spontaneous hypothermia with hyperhidrosis: implications for pathogenesis

R D Sheth1, T F Barron, P L Hartlage

  • 1Division of Pediatrics (Neurology), Memorial University of Newfoundland, Canada.

Pediatric Neurology
|February 1, 1994
PubMed
Summary
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Episodic spontaneous hypothermia with hyperhidrosis, a rare condition, may stem from specific brainstem dysfunction. Treatment with cyproheptadine showed promise in affected children, suggesting a serotonergic link.

Area of Science:

  • Neurology
  • Pediatrics
  • Endocrinology

Background:

  • Episodic spontaneous hypothermia with hyperhidrosis (ESH) is a rare condition with an unclear etiology.
  • Previous research linked ESH to congenital central nervous system malformations, specifically agenesis of the corpus callosum.

Observation:

  • This study reports on three unrelated children with ESH, all possessing an intact corpus callosum and normal endocrine function.
  • A notable observation was the consistent absence of shivering despite significant hypothermia.

Findings:

  • One child experienced spontaneous resolution of ESH symptoms.
  • Two children responded favorably to treatment with cyproheptadine, an antiserotonergic medication.

Implications:

Related Experiment Videos

  • These findings suggest that ESH may not solely be linked to midline CNS malformations.
  • The response to cyproheptadine supports the hypothesis of serotonergic dysfunction in the anterior hypothalamic shivering pathway as a key factor in ESH pathogenesis.