Related Experiment Videos
A physiologically based mathematical model of dermal absorption in man
T R Auton1, D R Westhead, B H Woollen
1Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, UK.
Human & Experimental Toxicology
|January 1, 1994
Summary
A new mathematical model simulates chemical absorption through skin layers, accounting for removal processes like washing and clothing contact. This aids toxicological risk assessment by quantifying skin penetration and surface loss.
Area of Science:
- Toxicology
- Dermatology
- Mathematical Modeling
Background:
- Understanding percutaneous absorption is crucial for assessing chemical risks to skin.
- Existing models may not fully capture complex skin interactions and removal processes.
Purpose of the Study:
- To develop a physiologically based mathematical model for percutaneous absorption.
- To simulate chemical transport and metabolism within skin layers and removal from the skin surface.
Main Methods:
- Developed a multi-layer mathematical model of human skin (surface, stratum corneum, viable tissue).
- Incorporated partitioning, diffusive transport, metabolism, washing, desquamation, and clothing transfer.
- Applied the model to fluazifop-butyl penetration data (in vivo and in vitro).
Main Results:
- A small fraction of the applied dose was absorbed through the skin.
- The majority of the chemical was removed via washing or onto clothing.
- The model quantitatively described these surface loss processes.
Conclusions:
- The developed model effectively simulates percutaneous absorption and surface removal.
- This physiologically based model enhances toxicological risk assessment for skin exposure.
- Accurate modeling of surface loss is critical for understanding overall chemical exposure.