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Neonatal renal candidiasis

S A Morris1, C J Bailey, J M Cartledge

  • 1Department of Paediatrics, Launceston General Hospital, Australia.

Journal of Paediatrics and Child Health
|April 1, 1994
PubMed
Summary
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Renal candidiasis in infants can cause obstructive uropathy. Treatment with fluconazole proved effective and less toxic than amphotericin B for neonatal kidney infections.

Area of Science:

  • Pediatric Nephrology
  • Mycology
  • Infectious Diseases

Background:

  • Neonatal renal candidiasis is a rare but serious infection.
  • Obstructive uropathy can be a severe complication of renal candidiasis in infants.

Observation:

  • A 4-month-old infant presented with renal candidiasis complicated by obstructive uropathy.
  • Initial management involved surgical decompression and amphotericin B.

Findings:

  • Persistent candiduria led to a switch from ketoconazole to fluconazole.
  • Fluconazole achieved rapid urinary sterilization, indicating its efficacy.
  • The treatment regimen was successful in managing the infant's condition.

Implications:

Related Experiment Videos

  • Fluconazole offers an effective and safer alternative to prolonged amphotericin B therapy for neonatal renal candidiasis.
  • This case highlights the successful use of fluconazole in treating complicated neonatal kidney infections.
  • Early diagnosis and appropriate antifungal therapy are crucial for favorable outcomes in infants with renal candidiasis.