Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renin lowers blood-pressure

D B Gordon

    Lancet (London, England)
    |November 4, 1978
    PubMed
    Summary

    This study proposes that higher plasma renin levels may lower blood pressure. Renin binding to vessel walls might cause vasodilation, counteracting angiotensin's effects and supporting this blood pressure regulation hypothesis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    PAIN OUT: the making of an international acute pain registry.

    European journal of pain (London, England)·2014
    Same author

    Opioid equianalgesic calculations.

    Journal of palliative medicine·2005
    Same author

    Are alpha-gliadins glycosylated?

    Protein and peptide letters·2002
    Same author

    Intact cell mass spectrometry (ICMS) used to type methicillin-resistant Staphylococcus aureus: media effects and inter-laboratory reproducibility.

    Journal of microbiological methods·2002
    Same author

    A nurse-run inpatient pain consultation service.

    Pain management nursing : official journal of the American Society of Pain Management Nurses·2001
    Same author

    Understanding equianalgesic dosing.

    Orthopedic nursing·2001

    Area of Science:

    • Cardiovascular Physiology
    • Renal System Biology

    Background:

    • The renin-angiotensin-aldosterone system (RAAS) is a key regulator of blood pressure.
    • Typically, renin initiates a cascade leading to angiotensin II, a potent vasoconstrictor that raises blood pressure.

    Purpose of the Study:

    • To propose and explore a novel hypothesis regarding renin's role in blood pressure regulation.
    • To investigate the potential of renin to lower blood pressure through direct vascular actions.

    Main Methods:

    • Postulation of renin binding to blood vessel walls.
    • Analysis of existing data on the effects of saralasin and converting-enzyme inhibitors.
    • Correlation of these effects with plasma and kidney renin concentrations.

    Main Results:

    • Evidence suggests renin binding to vessel walls may exert a vasodilator action.
    • This proposed vasodilator effect could oppose the vasoconstrictive effects of angiotensin.
    • Observed effects of pharmacological agents align with this hypothesis.

    Conclusions:

    • Increased plasma renin may have a hypotensive effect, challenging the traditional view.
    • Renin's interaction with blood vessel walls warrants further investigation for blood pressure control.
    • This hypothesis offers a new perspective on RAAS modulation for hypertension treatment.

    Related Experiment Videos