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The effects of perphenazine on self-administration behavior
Pharmacology, Biochemistry, and Behavior
|April 1, 1976
Summary
Perphenazine does not reinforce behavior and can decrease cocaine and pentobarbital self-administration in rhesus monkeys. It appears to antagonize some effects of cocaine.
Area of Science:
- Pharmacology
- Neuroscience
- Behavioral Science
Background:
- Understanding drug reinforcement and antagonism is crucial for addiction research.
- Perphenazine's effects on drug self-administration are not well-established.
Purpose of the Study:
- To investigate perphenazine's reinforcing properties.
- To determine if perphenazine can antagonize the effects of cocaine and pentobarbital in rhesus monkeys.
Main Methods:
- Rhesus monkeys self-administered cocaine or pentobarbital under a fixed-ratio schedule.
- Perphenazine was administered alone or as a pretreatment before drug self-administration.
Main Results:
- Perphenazine alone did not support responding, indicating it is not a positive reinforcer.
- Perphenazine increased cocaine self-administration at some doses but decreased it at higher doses.
- Perphenazine decreased pentobarbital self-administration and did not affect cocaine self-administration at doses that increased cocaine intake.
Conclusions:
- Perphenazine is not a positive reinforcer.
- Perphenazine exhibits complex interactions with cocaine and pentobarbital self-administration.
- Perphenazine may antagonize certain effects of cocaine.