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Related Experiment Videos

Elevated plasma adrenaline in spontaneously hypertensive rats

L T Jablonskis1, P R Howe

  • 1Division of Human Nutrition, Commonwealth Scientific and Industrial Research Organisation, Adelaide, Australia.

Blood Pressure
|March 1, 1994
PubMed
Summary

This study found that circulating adrenaline levels are significantly higher in hypertensive rat strains, correlating with elevated blood pressure and sympathetic nervous system activity.

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Area of Science:

  • Cardiovascular Physiology
  • Hypertension Research
  • Neuroendocrinology

Background:

  • Circulating adrenaline (AD) is elevated in stroke-prone spontaneously hypertensive rats (SHRSP).
  • Previous studies focused on SHRSP, necessitating a broader comparison across rat strains.

Purpose of the Study:

  • To compare plasma adrenaline (AD) and noradrenaline (NA) levels and their relationship with mean arterial pressure (MAP) across different rat strains.
  • To investigate the role of sympathetic nervous system activity in hypertension using ganglion blockade.

Main Methods:

  • Implanted aortic catheters in young and old Wistar-Kyoto (WKY), Black-Hooded Wistar (BHW), Sprague Dawley (SD), spontaneously hypertensive rats (SHR), and SHRSP.
  • Measured MAP and collected blood samples under conscious resting conditions.
  • Administered ganglion blockade to assess sympathetic contribution to blood pressure.

Main Results:

  • Young SHR and SHRSP had higher MAP than WKY; SD rats had similar MAP.
  • Plasma AD was higher in young SHR and lower in SD rats compared to WKY.
  • Older hypertensive strains (SHR, SHRSP) showed 3-4 times higher circulating AD than normotensive strains.
  • Plasma NA was elevated only in older SHR.
  • Ganglion blockade revealed greater sympathetic influence in older SHR and SHRSP.
  • Residual MAP after blockade was higher in hypertensive strains at both ages.
  • In older rats, plasma AD correlated with MAP, sympathetic activity, and plasma NA.

Conclusions:

  • Hypertensive rat strains exhibit elevated circulating adrenaline, particularly in older age.
  • Adrenaline levels are linked to resting blood pressure and sympathetic nervous system activity in hypertension.
  • These findings highlight the role of catecholamines in the development and maintenance of hypertension.

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