[Panmyelosis--a report of 4 cases]

From January 1987 to December 1990, 4 cases of panmyelosis were diagnosed in our hospital, which accounted for 1.36% of all acute nonlymphocytic leukemia cases. The clinical manifestation was similar to that of acute leukemia Hb ranged from 38 to 60 g/L, WBC 5.6 x 10(9)-14.0 x 10(9)/L, blasts in peripheral blood 1%-47%. Erythroblasts and megakaryocytes were also seen in peripheral blood. Platelets were 13 x 10(9)-240 x 10(9)/L. The myelogram showed hypercellularity. Myeloblast type I+type II accounted for 26.1%-51.6% of non-erythrocytic cells. Auer body could be seen in three cases and there was a leukemic gap in each. Erythrocytic series was 34.5%-84.5% with abnormal erythroblasts. PAS staining was positive in 60%-100% erythroblasts. Megakaryocytes were 545- > 1,000/1.5 cm x 3 cm and megakaryoblasts plus promegakaryocytes were 32%-43%. There were micro-megakaryoblasts like lymphocyte in size in marrow smear and PAS staining for megakaryocytes was strongly positive. The diagnostic criteria, differential diagnosis and treatment for the disease were discussed.