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Involvement of glutamate receptors in the striatal enkephalin-induced dopamine release
1Unité de Neuropsychopharmacologie Expérimentale, C.N.R.S.U.R.A. 1170, Faculté de Médecine & Pharmacie de Rouen, Saint Etienne du Rouvray, France.
Abstract:
In anesthetized rats, the intrastriatal infusion of the delta-opioid receptor agonist, [D-Pen2,D-Pen5]enkephalin, increased the extracellular concentration of dopamine. This effect was abolished by the NMDA receptor antagonist, 3-[(+/-)-2-carboxypiperazine-4-yl]propyl-1-phosphonate, but was unchanged by the AMPA (D,L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) and kainate receptor antagonist, 6,7-dinitroquinoxaline-2,3-dione. This suggests that the dopamine release induced by the delta-opioid agonist depends critically on the involvement of glutamatergic transmission via NMDA receptors.