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Buspirone enhances head twitch behavior in mice

Y Kitamura¹, T Nagatani, T Watanabe

¹First Laboratory for Pharmacological Research, Asahi Chemical Industry Co., Ltd., Miyazaki, Japan.

European Journal of Pharmacology

|March 3, 1994

Summary

Buspirone, a 5-HT1A receptor agonist, enhanced head twitching in mice. This effect, mediated by post-synaptic 5-HT1A receptor activation, was blocked by specific antagonists, confirming buspirone's role.

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Area of Science:

Neuropharmacology
Serotonergic system research

Background:

Buspirone is a 5-HT1A receptor agonist.
Head twitch behavior is a recognized indicator of serotonergic activity.

Purpose of the Study:

To investigate the effect of buspirone on 5-hydroxy-L-tryptophan (5-HTP)-induced head twitch behavior in mice.
To elucidate the role of post-synaptic 5-HT1A receptors in buspirone's action.

Main Methods:

Administration of buspirone, 5-HTP, and pargyline to mice.
Dose-response study of buspirone (0.1-10 mg/kg i.p.).
Assessment of the effects of antagonists like (-)-propranolol and NAN-190.
Evaluation of buspirone's effect after p-chlorophenylalanine pretreatment.

Main Results:

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Buspirone dose-dependently enhanced head twitch behavior induced by 5-HTP and pargyline.
The enhancing effect of buspirone was significantly blocked by (-)-propranolol and NAN-190.
Buspirone's enhancing effect persisted even after pretreatment with p-chlorophenylalanine.

Conclusions:

Buspirone enhances 5-HTP-induced head twitch behavior in mice.
This enhancement is likely mediated through the activation of post-synaptic 5-HT1A receptors.
The findings support the role of post-synaptic 5-HT1A receptor agonism in modulating serotonergic behaviors.