Activity oscillations predicted for pyruvate dehydrogenase complexes
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V A Selivanov1, D T Zakrzhevskaya, B N Goldstein
1Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region.
FEBS Letters
|May 30, 1994
Abstract:
A kinetic model for the pyruvate dehydrogenase complex is analyzed. The model takes into account intermediate channeling through the lipoyl network attached to the complex core, as well as inter-related regulatory effects of protein X acetylation and enzyme phosphorylation. The model predicts undamped oscillations of enzyme activity.