[The influence of thyroid and antithyroid preparations on the development of induced breast cancer]

Research Institute of Endocrinology and Hormone Chemistry, Khar'kov It was shown that realization of a neoplastic process in the breast is determined, in particular, by the chemical structure of agents employed and their dosage. So 1-thyroxine, depending on the dosage used, may stimulate the development of tumor process in mammary glands, but exert no influence on it (an effect of "the effect extinction"), and finely suppress tumor development. Among the determining factors the activity of thyreotropic function of the hypophysis and a concentration of an albumin bound form of thyroxine in blood are of special importance.