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Oxygen performance of a prototype nonconventional hydrogel

W J Benjamin1

  • 1University of Alabama at Birmingham School of Optometry 35294.

Journal of the American Optometric Association
|March 1, 1994
PubMed
Summary
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New hydrogel contact lens materials offer higher oxygen permeability (Dk) than conventional ones, surpassing water content limitations for improved physiological compatibility and potential for ultra-thin, highly transmissible lenses.

Area of Science:

  • Ophthalmic biomaterials science
  • Polymer chemistry
  • Contact lens technology

Background:

  • Conventional hydrogel contact lenses are limited by oxygen permeability (Dk), with a theoretical upper limit of 37 Dk units for high-water content materials.
  • Advancing physiological compatibility requires exploring methods to increase oxygen permeability beyond water content limitations.

Purpose of the Study:

  • To evaluate the oxygen transport characteristics of a prototype nonconventional hydrogel contact lens material.
  • To determine if this material can surpass the conventional relationship between water content and oxygen transmissibility.

Main Methods:

  • Oxygen permeability (Dk) and oxygen transmissibility (Dk/L) were computed for a prototype nonconventional hydrogel.
  • Material characteristics were assessed using human equivalent oxygen percentage (EOP) and lens thickness (L).

Related Experiment Videos

  • A recently published nonlinear EOP vs. Dk/L relationship was utilized for calculations.

    • Main Results:

    • The prototype nonconventional hydrogel exhibited an oxygen permeability (Dk) of approximately 35 Dk units, significantly higher than 12.7 Dk units for a conventional gel with similar water content (52% H2O).
    • This mid-water content material achieved oxygen permeability comparable to high-water conventional gels.
    • The material demonstrated potential for low critical thicknesses, characteristic of low-water conventional gels.

    Conclusions:

    • Nonconventional hydrogel materials may achieve "super" or "hyper" transmissibility (50-90 Dk/L) in ultra-thin lenses, surpassing conventional limits.
    • These materials could offer superior physiological compatibility for contact lens wear.
    • Further development is necessary to overcome hurdles before market readiness for ophthalmic applications.