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Related Experiment Videos

Renal agenesis: an acquired condition?

R Hitchcock1, D M Burge

  • 1Department of Pediatric Surgery, Southampton General Hospital, Hampshire, United Kingdom.

Journal of Pediatric Surgery
|March 1, 1994
PubMed
Summary
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Renal agenesis can result from prenatal involution of multicystic dysplastic kidneys (MDK) or hydronephrosis. This study shows that some cases diagnosed prenatally as MDK or hydronephrosis may resolve, appearing as renal agenesis postnatally.

Area of Science:

  • Pediatric Nephrology
  • Congenital Anomalies
  • Medical Imaging

Background:

  • Renal agenesis is a common congenital anomaly with an unknown etiology.
  • Some solitary kidneys result from postnatal involution of multicystic dysplastic kidneys (MDK).

Purpose of the Study:

  • To investigate the prenatal development and postnatal outcomes of neonates with suspected renal agenesis.
  • To explore the potential for prenatal involution of MDK and hydronephrosis leading to apparent renal agenesis.

Main Methods:

  • Retrospective analysis of nine neonates with abnormal prenatal renal ultrasound findings.
  • Postnatal investigations to confirm renal status.
  • Review of prenatal diagnoses including MDK and hydronephrosis.

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Main Results:

  • Five neonates had a prenatal diagnosis of MDK, and two had hydronephrosis.
  • Postnatal investigations revealed an absent kidney in all nine cases.
  • Contralateral renal unit anomalies were present in 56% of cases.
  • Prenatal involution of MDK and hydronephrosis was observed.

Conclusions:

  • Multicystic dysplastic kidney (MDK) and, occasionally, hydronephrosis can involute prenatally.
  • This prenatal involution can lead to the postnatal appearance of renal agenesis.
  • Prenatal imaging findings should be interpreted with awareness of potential involutional changes.