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Related Experiment Videos

Breast cancer prevention trial

E G Elias1, S D Brown, B S Buda

  • 1Department of Surgery, University of Maryland School of Medicine, Baltimore.

Maryland Medical Journal (Baltimore, Md. : 1985)
|March 1, 1994
PubMed
Summary

The Breast Cancer Prevention Trial (BCPT) investigates tamoxifen to reduce invasive breast cancer incidence and mortality. This large study randomizes 16,000 women to tamoxifen or placebo over five years.

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Area of Science:

  • Oncology
  • Clinical Trials
  • Preventive Medicine

Background:

  • Breast cancer incidence is increasing, affecting 1 in 8 women.
  • Early detection efforts have not fully curbed the rising incidence.
  • There is a need for effective preventive strategies against breast cancer.

Purpose of the Study:

  • To evaluate tamoxifen's efficacy in reducing invasive breast cancer.
  • To assess tamoxifen's impact on breast cancer and cardiovascular mortality.
  • To determine tamoxifen's effect on bone fracture incidence.

Main Methods:

  • The Breast Cancer Prevention Trial (BCPT) is a randomized, placebo-controlled study.
  • 16,000 healthy women aged 35+ will receive tamoxifen or placebo for five years.
  • The National Surgical Adjuvant Breast and Bowel Project (NSABBP) oversees the trial.

Main Results:

  • As of March 1993, 42% of the target 16,000 participants were enrolled.
  • Enrollment is ongoing, with a target of 16,000 women.
  • The trial is actively recruiting participants.

Conclusions:

  • Tamoxifen is being evaluated for its potential to prevent invasive breast cancer.
  • The study aims to provide crucial data on tamoxifen's benefits and risks.
  • Findings will inform future breast cancer prevention strategies.

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