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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
[Short-term prognosis in patients with congestive heart failure and normal left ventricular systolic function]
1Servicio de Internación del Centro Integral Médico (CIM), Buenos Aires, Argentina.
Insights
Congestive heart failure (CHF) patients with preserved left ventricular systolic function (LVSF) have a similar short-term prognosis to those with impaired LVSF. This finding challenges traditional assumptions about CHF prognosis.
Area of Science:
- Cardiology
- Internal Medicine
- Echocardiography
Context:
- Congestive heart failure (CHF) is typically linked to impaired left ventricular systolic function (LVSF).
- Limited data exists on the prognosis of CHF patients with preserved LVSF.
- This study addresses the clinical characteristics and short-term outcomes of CHF patients with varying LVSF.
Purpose:
- To describe a cohort of 70 patients admitted for CHF.
- To assess left ventricular systolic function using echocardiography.
- To determine the short-term prognosis in patients with and without impaired LVSF.
Summary:
- Of 70 CHF patients, 54.3% had impaired LVSF and 45.7% had preserved LVSF.
- No significant difference in overall mortality was observed between groups during an 8-month follow-up.
- Multivariate analysis found no significant prognostic covariates including LVSF.
Impact:
- Nearly half of the studied CHF patients presented with normal LVSF.
- Short-term prognosis for CHF patients is similar regardless of LVSF status.
- Findings suggest a need to re-evaluate diagnostic and prognostic criteria for CHF.
Abstract:
Congestive heart failure (CHF) has been traditionally associated with impairment of the left ventricular systolic function (LVSF). There are few clinical assays that describe the prognosis of patients with CHF and intact LVSF. The aims of this prospective assay are: to describe a group of 70 patients admitted to an internal medicine department with the clinical syndrome of CHF, to determine the contractile state of the left ventricle with echocardiography and to establish the short term prognosis. There were 39 males and 31 females with a mean age of 76.4. The LVSF was impaired in 38 (54.3%) [Group I] and preserved in 32 (45.7%) [Group II] (Table 1). Sex distribution was different between both groups with women predominating in group II (Figure 1). Fourteen patients belonging to Group II had diastolic function impairment according to cardiac Doppler. There was no other evidence of cardiac abnormality that could justify CHF. During an average of 8 months follow-up 20 (28%) patients died. There were no differences in overall mortality between Groups I and II (Figure 2). Multivariate analysis was used to determine the relative risk in prognosis of the covariates age, gender, systolic function and diameters of the LV. None of these were statistically significant (Table 2). In our series 45.7% of the patients with CHF had normal LVSF. The short term prognosis proved to be the same in patients with and without impaired LVSF.
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