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Related Experiment Videos

Acidosis and bone

D A Bushinsky1

  • 1Department of Medicine and Physiology, University of Rochester School of Medicine and Dentistry, NY 14642.

Mineral and Electrolyte Metabolism
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Metabolic acidosis causes calcium efflux from bone by altering mineral dynamics and stimulating bone resorption. Respiratory acidosis has a lesser effect on bone calcium flux.

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Area of Science:

  • Biochemistry
  • Physiology
  • Mineral Metabolism

Background:

  • Acidosis, a condition affecting acid-base balance, significantly impacts bone mineral.
  • Neonatal mouse calvariae in organ culture provide a model to study these effects.

Purpose of the Study:

  • To investigate the effects of metabolic and respiratory acidosis on bone mineral.
  • To elucidate the mechanisms of calcium efflux and proton exchange in bone during acidosis.

Main Methods:

  • Organ culture of neonatal mouse calvariae.
  • Exposure to acute and chronic models of metabolic and respiratory acidosis.
  • High-resolution scanning ion microprobe analysis of bone mineral.

Main Results:

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  • Metabolic acidosis (low bicarbonate) induced net calcium efflux and proton influx, with protons exchanging for sodium and potassium on the bone surface.
  • Acute metabolic acidosis mobilized carbonated apatite, while chronic acidosis stimulated osteoclastic resorption and inhibited osteoblastic formation.
  • Respiratory acidosis (high CO2) also caused calcium efflux, but to a lesser extent than metabolic acidosis, with no measurable proton influx into bone.

    • Conclusions:

    • Metabolic acidosis significantly impacts bone mineral homeostasis through physicochemical changes and cellular activity.
    • Respiratory acidosis has a less pronounced effect on bone calcium flux compared to metabolic acidosis.
    • Understanding these mechanisms is crucial for managing bone health in acidosis patients.