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Metabolic acidosis and bone disease
1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock 79430.
Mineral and Electrolyte Metabolism
|January 1, 1994
Summary
Bone acts as the body's largest buffer, crucial for acid-base balance. This review explores bone's buffering role, focusing on parathyroid hormone (PTH) and vitamin D, and related bone conditions.
Area of Science:
- Physiology
- Biochemistry
- Bone Biology
Background:
- Bone serves as the primary reservoir for buffering excess acid in the body.
- Maintaining acid-base homeostasis is vital for organism survival.
- Altered acid-base balance can significantly impact bone health.
Purpose of the Study:
- To elucidate the critical role of bone buffering in maintaining acid-base homeostasis.
- To emphasize the involvement of parathyroid hormone (PTH) and vitamin D in bone buffering.
- To examine bone abnormalities associated with acid-base disorders.
Main Methods:
- Literature review of bone physiology and acid-base balance.
- Analysis of the mechanisms of bone buffering.
- Discussion of the roles of PTH and vitamin D in bone metabolism and acid-base regulation.
Main Results:
- Bone actively participates in buffering systemic acid loads.
- Parathyroid hormone (PTH) and vitamin D are key regulators of bone's acid-base contribution.
- Bone abnormalities are observed in conditions like renal tubular acidosis and chronic renal failure.
Conclusions:
- Bone plays an indispensable role in acid-base homeostasis.
- Understanding the interplay between bone, PTH, and vitamin D is crucial for managing acid-base disorders.
- Further research into bone abnormalities in renal diseases is warranted.