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Related Experiment Videos

Tea plant root extract (TRE) as an antineoplastic agent

P Sur1, D K Ganguly

  • 1Division of Pharmacology & Experimental Therapeutics, Indian Institute of Chemical Biology, Calcutta.

Planta Medica
|April 1, 1994
PubMed
Summary

Tea plant root extract (TRE) shows significant antitumour effects against Ehrlich ascites carcinoma (EAC) in mice. TRE treatment prolonged survival and inhibited tumor growth, offering a potential natural therapeutic agent.

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Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products

Background:

  • Ehrlich ascites carcinoma (EAC) is a common model for studying cancer progression and treatment efficacy.
  • Investigating natural compounds for anticancer properties is crucial for developing novel therapeutic strategies.

Purpose of the Study:

  • To evaluate the antitumour effect of tea plant root extract (TRE) against EAC in a murine model.
  • To assess the impact of TRE on survival rates, tumor growth, and hematological parameters in tumor-bearing mice.

Main Methods:

  • Balb-C mice were inoculated with EAC cells.
  • TRE was administered to tumor-bearing mice.
  • Survival times, tumor cell proliferation, and hematological parameters were monitored and compared to a control group.

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Main Results:

  • TRE administration significantly increased the survival times of EAC-bearing mice compared to controls.
  • TRE effectively inhibited tumor cell growth in vivo.
  • TRE treatment reversed hematological abnormalities induced by EAC inoculation.

Conclusions:

  • Tea plant root extract demonstrates significant antitumour activity against Ehrlich ascites carcinoma in mice.
  • TRE prolongs survival and mitigates tumor-induced pathological changes, highlighting its therapeutic potential.