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Biologically active triterpene saponins from Bupleurum fruticosum
M C Guinea1, J Parellada, M A Lacaille-Dubois
1Departmento de Farmacia y Tecnología Farmacéutica, Universidad de Alcalá de Henares, Madrid, Spain.
Planta Medica
|April 1, 1994
Summary
Buddleja fruticosum root extracts exhibit significant hepatoprotective effects, stimulating phagocytosis and inhibiting leucine aminopeptidase. Researchers isolated buddlejasaponin IV and a novel malonylbuddlejasaponin IV, confirming their protective properties.
Area of Science:
- Phytochemistry
- Pharmacology
- Natural Products Chemistry
Background:
- Buddleja fruticosum L. is a plant with a history of traditional medicinal use.
- Previous studies suggest potential biological activities of B. fruticosum extracts.
Purpose of the Study:
- To investigate the biological activities of B. fruticosum root extracts.
- To isolate and identify compounds responsible for the observed hepatoprotective effects.
Main Methods:
- Biological screening of B. fruticosum root extracts for various activities.
- Fractionation of extracts to isolate active compounds.
- Structure elucidation using chemical and spectroscopic methods (NMR, Mass Spectrometry).
Main Results:
- Extracts demonstrated hemolytical activity, hepatoprotective effects, phagocytosis stimulation, and leucine aminopeptidase inhibition.
- Hepatoprotective activity was attributed to isolated saikosaponins: buddlejasaponin IV and a new compound, malonylbuddlejasaponin IV (saikogenin F-3-O-[6-O-malonyl-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl (1-->3)]-beta-D-fucopyranoside).
Conclusions:
- Buddleja fruticosum root contains compounds with significant hepatoprotective and immunomodulatory properties.
- The identified saikosaponins, particularly buddlejasaponin IV and its malonyl derivative, are key contributors to the plant's medicinal potential.