Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fisher's game with the devil

S Senn1

  • 1Medicines and Clinical Development Department, Pharmaceuticals Division, CIBA Ltd., Basle, Switzerland.

Statistics in Medicine
|February 15, 1994
PubMed
Summary
This summary is machine-generated.

Fisher

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of humeral head osteochondrosis in the Greater Swiss Mountain dog and the Border Collie in Switzerland.

Schweizer Archiv fur Tierheilkunde·2016
Same author

A 4-year trial of tiotropium in chronic obstructive pulmonary disease (UPLIFT trial).

Revista portuguesa de pneumologia·2015
Same author

Statisticians and pharmacokineticists: what they can still learn from each other.

Clinical pharmacology and therapeutics·2010
Same author

Ethical considerations concerning treatment allocation in drug development trials.

Statistical methods in medical research·2002
Same author

Actions other than smooth muscle relaxation may play a role in the protective effects of formoterol on the allergen-induced late asthmatic reaction.

Pulmonary pharmacology & therapeutics·2002
Same author

Screening for breast cancer with mammography.

Lancet (London, England)·2002
Same journal

Interpretable Bayesian Modeling for Multireader Multicase Studies: Addressing Overdispersion and Limited Sample Size in Diagnostic Enhancement Evaluation.

Statistics in medicine·2026
Same journal

Adaptive Sequential Multiple Hypotheses Testing for Concomitant Vaccine Safety Surveillance.

Statistics in medicine·2026
Same journal

Novel Distance Regression for Repeated Outcomes With Missing Data: Applications to Longitudinal and Crossover Studies of Microbiome Beta-Diversity.

Statistics in medicine·2026
Same journal

Optimal Weighted Tests for Replication Studies and the 'Two-Trials Rule' With Multiple Hypotheses.

Statistics in medicine·2026
Same journal

Identifiable Copula-Double-Cox Models: A Fully Parametric Framework for Dependent Right-Censored Survival Data.

Statistics in medicine·2026
Same journal

Moving From Individualized Risk-Based Prevention to Benefit-Based Prevention: Estimating Individualized Life-Years Gained From Prevention Services as a Basis for Eligibility.

Statistics in medicine·2026
See all related articles

Area of Science:

  • Statistics and Biostatistics
  • Clinical Trial Methodology

Background:

  • Fisher's statistical principles are foundational.
  • Understanding randomization's historical context is crucial for modern research.

Purpose of the Study:

  • To re-examine Sir Ronald Fisher's views on randomization.
  • To demonstrate the enduring relevance of Fisher's statistical insights for clinical trials.

Main Methods:

  • Analysis of Fisher's published correspondence.
  • Review of Fisher's seminal works on experimental design.
  • Application of historical statistical concepts to contemporary clinical trial practices.

Main Results:

  • Fisher's perspectives on randomization are consistent and well-defined.

Related Experiment Videos

  • His early work, though focused on agriculture, provides valuable frameworks.
  • Fisher's principles remain highly applicable to clinical trial design and analysis.

    • Conclusions:

    • Fisher's statistical theories on randomization are coherent and timeless.
    • His insights from agricultural experiments offer enduring guidance for clinical research.
    • Modern clinical trials benefit significantly from understanding and applying Fisher's foundational concepts of randomization.