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Toxicity of monocyclic and polycyclic nitroaromatic compounds in a panel of mammalian test cell lines
M M Perchermeier1, F Kiefer, F J Wiebel
1Institute of Toxicology, GSF-Forschungszentrum für Umwelt und Gesundheit, Neuherberg, Germany.
Abstract:
The cytotoxicity of polycyclic and monocyclic nitroarenes was tested in cell lines V79/NH, H4IIEC3/G-, 5L and BWI-J, which are distinguished by their specific expression of xenobiotic metabolizing enzymes. The results show that polycyclic nitroarenes differentially affect the test cell lines suggesting that some compounds, such as 1,3-dinitropyrene, are activated by cytochrome P4501A1, others, such as 1,6-dinitropyrene, by reductase(s) and acetyltransferase. No such cell specific responses were seen for 13 monocyclic nitroarenes tested. This group of chemicals apparently is activated by an enzyme(s) other than the polycyclic nitroarenes tested.