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Related Experiment Videos

Craniofacial duplication (diprosopus) in a twin

D G Changaris, M H McGavran

    Archives of Pathology & Laboratory Medicine
    |July 1, 1976
    PubMed
    Summary

    A rare case of a fused, double-faced (diprosopus) anencephalic monster was observed. Autopsy findings and literature review suggest factors beyond the fetal environment may influence this severe congenital defect.

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    Area of Science:

    • Teratology
    • Developmental Biology
    • Pathology

    Background:

    • Diprosopus, a rare congenital anomaly characterized by facial duplication, presents significant challenges in understanding its etiology.
    • Anencephaly, the absence of a major portion of the brain and skull, is a severe neural tube defect often incompatible with life.

    Observation:

    • A premature twin, delivered at 30 weeks gestation, exhibited a fused, double-faced (diprosopus) and anencephalic presentation.
    • Detailed autopsy was performed to document the anatomical abnormalities associated with this complex malformation.

    Findings:

    • The autopsy revealed a spectrum of anomalies consistent with both diprosopus and anencephaly.
    • A review of existing literature on diprosopus was conducted to contextualize these findings.

    Implications:

    • The pathogenesis of diprosopus may involve a complex interplay of genetic and environmental factors.
    • Further research is needed to elucidate the specific mechanisms contributing to this rare congenital defect.

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