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5-HT1A receptor agonists reduce ethanol-induced locomotor activity in mice
O Blomqvist1, B Söderpalm, J A Engel
1Department of Pharmacology, University of Göteborg, Sweden.
Abstract:
Animal studies as well as clinical studies have suggested that the brain 5-HT system is important for the regulation of voluntary ethanol intake and preference. Previous studies have suggested that 5-HT1A receptor agonists may reduce ethanol preference in rats. In the present study on mice, the 5-HT1A receptor agonists (8-OH-DPAT), ipsapirone, and buspirone all antagonized the locomotor activity (LMA) stimulatory effect of ethanol (2.5 g/kg). The present results provide further support for the notion that the LMA-increasing effect of ethanol may be homologous to its reinforcing properties and that 5-HT1A receptor agonists may counteract these properties as well.