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Human recombinant granulocyte-macrophage colony-stimulating factor in pediatric oncology practice
T Ferencz1, C Csaki, D Schuler
12nd Department of Pediatrics, Semmelweis Medical School, Budapest, Hungary.
Pediatric Hematology and Oncology
|March 1, 1994
Abstract:
This paper reports preliminary experiences with human recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) in children with malignant diseases administered for three indications: (1) chemotherapy-induced neutropenia and sepsis, (2) prolonged neutropenia decreasing dose intensity, and (3) prevention of neutropenia after sublethal doses of chemotherapy. It was concluded that in the daily dose of 5 micrograms/kg subcutaneously, GM-CSF is capable of reducing the duration of chemotherapy-induced neutropenia and may be an effective tool in maintaining dose intensity and achieving dose escalation.