Related Experiment Video
Updated: Oct 7, 2026

Measuring Psoriasis Severity at Home
Published on: March 1, 2024
An association between psoriasis and hereditary multiple exostoses. A clue for the mapping of a psoriasis
J L Rosbotham1, R C Trembath, M Glover
1Department of Genetics, University of Leicester, U.K.
Abstract:
Chronic plaque psoriasis affects approximately 1.6% of the U.K. population. Population, family and twin studies all strongly suggest an important genetic component in the pathogenesis of the disease, although genetic linkage studies have, so far, failed to identify susceptibility genes. We describe a family in which psoriasis cosegregates through three generations with a known autosomal dominant disorder, hereditary multiple exostoses (HME). A major locus for HME has recently been mapped to chromosome 8q. Observations in this family may provide a mapping clue for a psoriasis susceptibility gene.
Related Concept Videos
Genetic Lingo
Pedigree Analysis
Pleiotropy
Epistasis Analysis
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Multiple Sclerosis l: Introduction