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Related Experiment Videos

Assisted circulation without systemic heparinization

B M Weiss1, L K von Segesser, M I Turina

  • 1Institute of Anesthesiology, University Hospital Zürich, Switzerland.

Journal of Cardiothoracic and Vascular Anesthesia
|April 1, 1994
PubMed
Summary
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Heparin-coated equipment for partial left heart bypass (LHBP) significantly reduced blood loss and fluid requirements compared to standard circuits. This approach offers a safer alternative for extracorporeal circulation, improving patient outcomes.

Area of Science:

  • Biomaterials Science
  • Cardiovascular Surgery
  • Medical Device Engineering

Background:

  • Extracorporeal circulation requires improved materials and equipment for enhanced safety and efficacy.
  • Heparin-coated surfaces demonstrate sufficient thromboresistance, making them suitable for artificial perfusion applications.

Purpose of the Study:

  • To evaluate the efficacy and safety of heparin-coated equipment in a partial left heart bypass (LHBP) model.
  • To compare outcomes of LHBP using heparin-coated circuits versus standard circuits without systemic heparinization.

Main Methods:

  • Partial left heart bypass (LHBP) was performed in 10 dogs using servo-controlled roller pumps for 6 hours.
  • Heparin surface-coated equipment was utilized, eliminating the need for additional systemic heparinization.

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  • Hemodynamic parameters, blood loss, fluid requirements, and oxygen delivery were monitored and compared between groups.

    • Main Results:

    • LHBP with heparin-coated equipment resulted in significantly lower blood loss (204 mL vs. 1,240 mL) and fluid substitution needs (647 mL vs. 1,860 mL).
    • Higher mean aortic pressure (65-69 mmHg vs. 62-38 mmHg) and hemoglobin concentration (9.1 g/dL vs. 3.9 g/dL) were observed with heparin-coated circuits.
    • Oxygen delivery remained stable with heparin-coated LHBP, unlike the descending trend seen with standard circuits.

    Conclusions:

    • Heparin-coated equipment provides a safe and effective alternative for partial left heart bypass, minimizing complications associated with systemic heparinization.
    • This technology significantly improves blood conservation and reduces the need for fluid replacement during extracorporeal circulation.
    • The study supports the use of heparin-coated devices to maintain stable physiological parameters and improve patient safety in cardiac procedures.