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Related Experiment Videos

[The C-Jun oncoprotein]

M Castellazzi1, A Sergeant

  • 1Laboratoire de biologie moléculaire et cellulaire, UMR49, CNRS-ENS de Lyon, France.

Bulletin Du Cancer
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

Activator Protein-1 (AP-1), a complex including Jun and Fos proteins, regulates cell proliferation and oncogenesis. Constitutive AP-1 activation drives cell transformation, highlighting its role in cancer development.

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Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Oncology

Context:

  • Jun and Fos proteins form the Activator Protein-1 (AP-1) transcriptional complex.
  • AP-1 binds to TPA Responsive Elements (TRE) or AP-1 sites, regulating gene expression.
  • c-jun transcription is rapidly induced by extracellular signals, including growth factors and DNA-damaging agents.

Purpose:

  • To elucidate the mechanism of c-jun transcriptional activation.
  • To investigate the role of AP-1 in cell proliferation and oncogenesis.
  • To explore the function of c-Jun homodimers in cell transformation.

Summary:

  • c-jun transcriptional activation involves posttranscriptional modification of pre-existing c-Jun protein, followed by activation of its own transcription and AP-1-dependent genes.

Related Experiment Videos

  • Modifications of c-Jun include dephosphorylation, phosphorylation, and oxidation-reduction.
  • AP-1 activity is modulated by heterodimerization with other bZIP proteins and interference with other transcription factors.

    • Impact:

    • Constitutive AP-1 activation leads to in vitro cell transformation, likely via c-Jun:c-Jun homodimer accumulation.
    • Engineered c-Jun proteins forming only homodimers efficiently transform primary cells.
    • These findings provide tools to identify novel AP-1-dependent functions in cell proliferation control.