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Vascular melatonin receptors

M Viswanathan1, J T Laitinen, J M Saavedra

  • 1Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892.

Biological Signals
|July 1, 1993
PubMed
Summary
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Vascular melatonin receptors are found in rat arteries and may regulate blood flow and body temperature. Their expression varies with age, sex, and genetics.

Area of Science:

  • Cardiovascular Physiology
  • Neuroendocrinology

Background:

  • Melatonin receptors are known in the central nervous system.
  • Their presence and function in the vasculature are less understood.

Purpose of the Study:

  • To investigate the presence and characteristics of melatonin receptors in the rat vasculature.
  • To explore the functional role of melatonin in regulating vascular tone and its potential link to thermoregulation.

Main Methods:

  • Receptor binding studies in arterial tissues.
  • Analysis of receptor expression in different rat strains, ages, and sexes.
  • Functional assays using the rat caudal artery to assess melatonin's effect on vascular tone.

Main Results:

  • High-affinity melatonin receptors are expressed in the rat tail artery and Circle of Willis arteries.

Related Experiment Videos

  • Vascular melatonin receptor characteristics resemble those in the central nervous system.
  • Receptor expression is influenced by rat strain, age, and female reproductive hormones.
  • Melatonin influences vascular tone in the rat caudal artery.

    • Conclusions:

    • Vascular melatonin receptors are present in specific arteries of the rat.
    • Melatonin plays a role in regulating vascular tone.
    • The distribution suggests a role in thermoregulatory homeostasis.