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Analysis of herpesvirus genomes in Kikuchi's disease
Y Sumiyoshi1, M Kikuchi, T Minematu
1First Department of Pathology, School of Medicine, Fukuoka University, Japan.
Virchows Archiv : an International Journal of Pathology
|January 1, 1994
Abstract:
We examined the cervical lymph nodes of 30 patients with Kikuchi's disease and 15 patients with non-specific lymphadenitis, using Southern blot analysis and polymerase chain reaction (PCR) to identify human herpesviruses such as Epstein-Barr virus (EBV), cytomegalovirus, herpes simplex virus, and varicella-zoster virus. By Southern blot analysis, no virus DNA was recognized, but 16 of the 30 nodes from patients with Kikuchi's disease and 8 of the 15 nodes from patients with non-specific lymphadenitis showed amplified EBV DNA by PCR.