Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

A case of IgD-lambda myeloma

J Jákó, S Virágh, G Brooser

|January 1, 1975

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Case of Poisoning by Lead in Maccouba Snuff.

Western journal of medicine and surgery·2024

Same author

Action of Different Medicines on the Mental Faculties.

The Dental register·2021

Same author

Cutaneous lymphatic amyloid deposits in "Hungarian-type" familial transthyretin amyloidosis: a case report.

The British journal of dermatology·2002

Same author

Identification of P-selectin glycoprotein ligand-1 as a useful marker in acute myeloid leukaemias.

British journal of haematology·2002

Same author

[Prognostic significance of retinal microaneurysm number and localization in type-1 diabetes mellitus].

Orvosi hetilap·2001

Same author

[Role of thalidomide in the treatment of multiple myeloma].

Orvosi hetilap·2001

This case study details IgD myeloma leading to kidney failure and death. Treatment with cytostatic therapy reduced IgD levels, showing drug effects on plasmocytes and chromosomal changes.

Area of Science:

Nephrology
Hematology
Oncology

Background:

Presents a rare case of Immunoglobulin D (IgD) myeloma.
Highlights the aggressive nature and severe complications associated with this subtype of multiple myeloma.

Observation:

The patient presented with severe kidney damage leading to uremia and a fatal outcome.
Ophthalmic examination using fluorescein angiography did not reveal characteristic paraproteinemic fundus changes.
Serum IgD levels were significantly elevated at 1000 mg/100 ml, decreasing to 400 mg/100 ml with treatment.

Findings:

Cytostatic therapy demonstrated a notable reduction in elevated serum IgD levels.
Microphotograms confirmed the cytotoxic effects of antineoplastic drugs on plasma cells.
Karyotyping analysis revealed multiple chromosomal abnormalities in the patient's cells.

Related Experiment Videos

Implications:

This case underscores the critical impact of IgD myeloma on renal function and patient survival.
The study demonstrates the efficacy of cytostatic therapy in managing hypergammaglobulinemia in IgD myeloma.
Further research into the genetic and cellular mechanisms of IgD myeloma is warranted for improved therapeutic strategies.