Distribution and developmental change of vasopressin V1A and V2 receptor mRNA in rats

¹Department of Molecular and Cellular Pharmacology, National Children's Medical Research Center, Tokyo, Japan.

|March 15, 1994

Abstract:

With the reverse transcription-polymerase chain reaction (RT-PCR) method, we examined the tissue distribution of vasopressin V1A and V2 receptor transcripts in newborn and adult rats. In adult rats, vasopressin V1A receptor mRNA was detected in the brain, lung, liver and kidney, whereas vasopressin V2 receptor mRNA was found only in the kidney. In newborn rats, vasopressin V1A receptor mRNA was detected in the brain, liver, heart and kidney, whereas vasopressin V2 receptor mRNA in the kidney and brain. In the newborn rat brain the level of vasopressin V2 receptor mRNA decreased with age, and could not be detected in rats older than 2 weeks. Our results first demonstrated the extrarenal expression of vasopressin V2 receptor in the newborn rat brain. Also, the study showed that expressions of vasopressin V1A and V2 receptor mRNA transcripts are dynamically altered in the process of development.

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Abstract:

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