Copper pumping ATPases: common concepts in bacteria and man
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M Solioz1, A Odermatt, R Krapf
1Department of Clinical Pharmacology, University of Berne, Switzerland.
FEBS Letters
|June 6, 1994
Abstract:
Recently, four genes encoding putative copper pumping ATPases have been cloned from widely different sources: two genes from Enterococcus hirae that are involved in copper metabolism and two human genes that are defective in the copper-related Wilson and Menkes disease. The predicted gene products are P-type ATPases. They exhibit extensive sequence similarity and appear to be members of a new class of ATP driven copper pumps involved in the regulation of cellular copper.