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A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII
1Center for Advanced Biotechnology and Medicine, Piscataway, NJ 08854.
Gene
|June 10, 1994
Abstract:
A 1.2-kb cDNA clone isolated from a HeLa cell library contains an open reading frame encoding a new protein (p21) of 21 kDa that is approx. 48% similar to members of the eukaryotic transcription elongation factor SII (TFIIS) family. The deduced amino-acid sequence of p21 indicates that it is hydrophilic, basic and contains nuclear localization signals, as well as multiple consensus phosphorylation sites.