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Modified polyriboinosinic-polyribocytidylic acid, an immunological adjuvant
Infection and Immunity
|July 1, 1976
Summary
Polyriboinosinic-polyribocytidylic acid stabilized with poly-1-lysine and carboxymethylcellulose (PICLC) acts as a potent adjuvant. PICLC significantly enhanced antibody responses in rhesus monkeys vaccinated with Venezuelan equine encephalomyelitis virus vaccine.
Area of Science:
- Immunology
- Vaccinology
- Biochemistry
Background:
- Polyriboinosinic-polyribocytidylic acid is susceptible to enzymatic degradation.
- Adjuvants are crucial for enhancing vaccine immunogenicity.
Purpose of the Study:
- To evaluate the adjuvanticity of stabilized polyriboinosinic-polyribocytidylic acid (PICLC).
- To assess the impact of PICLC on the antibody response to a Venezuelan equine encephalomyelitis virus vaccine.
Main Methods:
- Stabilization of polyriboinosinic-polyribocytidylic acid with poly-1-lysine and carboxymethylcellulose to form PICLC.
- Vaccination of rhesus monkeys with formalin-inactivated Venezuelan equine encephalomyelitis virus vaccine, with or without PICLC.
- Measurement of primary antibody response and its maintenance over time.
Main Results:
- PICLC demonstrated marked adjuvanticity.
- The antibody response to the Venezuelan equine encephalomyelitis virus vaccine was significantly potentiated by PICLC.
- Elevated antibody levels were sustained for at least 2.5 months postvaccination.
Conclusions:
- PICLC is an effective adjuvant for enhancing vaccine-induced antibody responses.
- PICLC-adjuvanted vaccines may elicit immunological responses comparable to live, attenuated vaccines.
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