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Somatostatin does not suppress plasma parathyroid hormone
The Journal of Clinical Endocrinology and Metabolism
|July 1, 1976
Summary
Somatostatin did not affect plasma parathyroid hormone (PTH) levels in subjects with normal parathyroid function or a parathyroid adenoma. This study indicates somatostatin does not suppress PTH secretion.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Parathyroid hormone (PTH) regulates calcium and phosphate metabolism.
- Somatostatin is a hormone with diverse inhibitory effects on endocrine secretions.
Purpose of the Study:
- To investigate the effect of somatostatin on plasma parathyroid hormone (PTH) levels.
- To determine if somatostatin suppresses PTH secretion in humans.
Main Methods:
- Radioimmunoassay was used to measure plasma PTH levels.
- Somatostatin was infused intravenously at a rate of 500 mug/h for 4 hours in 6 subjects with normal parathyroid function and 1 patient with a parathyroid adenoma.
- In 2 subjects, PTH responses to EDTA were compared during simultaneous infusions of somatostatin and EDTA.
Main Results:
- No discernible effect of somatostatin infusion on plasma PTH levels was observed in any subject.
- Plasma PTH levels remained unchanged during somatostatin infusion, even in the presence of a parathyroid adenoma.
Conclusions:
- Somatostatin does not suppress plasma parathyroid hormone (PTH) secretion.
- These findings suggest that somatostatin's inhibitory actions do not extend to parathyroid hormone regulation.