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Modulation of intraocular pressure by adenosine agonists
1Department of Ophthalmology and Visual Sciences, Texas Tech University Health Sciences Center, Lubbock.
Journal of Ocular Pharmacology
|January 1, 1994
Summary
Adenosine receptors modulate intraocular pressure (IOP). Activation of A1 receptors with N6-cyclopentyladenosine (CPA) reduced IOP, suggesting a role in ocular function.
Area of Science:
- Ophthalmology
- Pharmacology
- Neuroscience
Background:
- Adenosine receptors influence physiological functions.
- Their role in ocular function and intraocular pressure (IOP) modulation is not well understood.
Purpose of the Study:
- To investigate the role of adenosine receptors in modulating intraocular pressure (IOP).
- To evaluate the effects of specific adenosine receptor agonists on IOP and cAMP levels.
Main Methods:
- Topical administration of adenosine agonists (NECA, CPA, CV-1808) in rabbits.
- Measurement of intraocular pressure (IOP).
- Assessment of cAMP accumulation in isolated iris/ciliary body tissue.
Main Results:
- 5'-N-ethylcarboxamideadenosine (NECA) reduced IOP but caused initial ocular hypertension.
- N6-cyclopentyladenosine (CPA) reduced IOP without hypertension.
- 8-phenylaminoadenosine (CV-1808) caused initial ocular hypertension.
- CPA dose-dependently suppressed forskolin-induced cAMP accumulation in iris/ciliary body.
Conclusions:
- Adenosine agonists can modulate IOP.
- Ocular hypotension is linked to adenosine A1 receptor activation.
- Modulation of cAMP levels in the iris/ciliary body may be involved in adenosine's effect on IOP.