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Updated: Jul 27, 2026
06:45
Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis
Published on: December 18, 2010
[The means of eliminating the intoxication in suppurative peritonitis]
Klinicheskaia Khirurgiia
|January 1, 1993
Abstract:
On the basis of experience with treatment of 351 patient with purulent peritonitis, the authors have drawn a conclusion about the expedience of cascade increasing the intensity of detoxication therapy depending on pronouncement of intoxication. Resulting from complex use of electrostimulation of the intestine, unloading stoma, hemosorption, ultraviolet blood irradiation, intra-aortal administration of drugs, the mortality in patients with severe intoxication decreased by 7.5%.
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01:09Methods for Studying Drug Absorption: In situ
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...