Related Experiment Videos
Turcot's syndrome: evidence for linkage to the adenomatous polyposis coli (APC) locus
D M Lasser1, D C DeVivo, J Garvin
1Department of Neurology, College of Physicians and Surgeons of Columbia University, New York, NY.
Objective:
To investigate the possibility that neuroepithelial tumors in Turcot's syndrome are caused by pleiotropic mutations in the gene for adenomatous polyposis coli (APC), a tumor-suppressor gene implicated in colonic cancer.
Methods:
We studied the inheritance patterns of genetic markers for the chromosome 5q21 region in 12 members of a Turcot's syndrome kindred with five affected members. We performed linkage analysis to detect linkage between the disease phenotype and DNA markers.
Results:
Marker D5S346, located 30 to 70 kilobases from the APC locus, showed evidence highly suggestive of linkage to the disease phenotype (lod score = 1.92).
Conclusions:
The data provide evidence that the tumor-suppressor gene implicated in APC and sporadic colon cancers may also cause malignant neuroepithelial tumors in Turcot's syndrome.