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CSF neuron-specific enolase after methohexital activation during electrocorticography
A L Rabinowicz1, J D Correale, W T Couldwell
1Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.
Neurology
|June 1, 1994
Summary
Cerebrospinal fluid neuron-specific enolase (NSE) increased significantly after methohexital activation in epilepsy surgery patients. This finding supports CSF NSE as a marker for acute seizure activity.
Area of Science:
- Neuroscience
- Biochemistry
Background:
- Neuron-specific enolase (NSE) is a key enzyme in brain energy metabolism.
- NSE is recognized as a sensitive marker for neuronal injury.
Purpose of the Study:
- To investigate changes in cerebrospinal fluid (CSF) and serum NSE levels.
- To assess NSE as a potential biomarker for seizure activity.
Main Methods:
- Measured CSF and serum NSE concentrations before and after methohexital infusion.
- Electrocorticography was performed during epilepsy surgery in three patients.
Main Results:
- CSF NSE levels demonstrated a three- to fourfold increase within 60 minutes post-methohexital infusion.
- Serum NSE levels remained unchanged throughout the study period.
Conclusions:
- CSF NSE levels acutely rise following the induction of epileptiform activity.
- CSF NSE is a potential biomarker for detecting seizure activity.